EVALUATION OF IP3R3 GENE SILENCING EFFECT ON PYRUVATE DEHYDROGENASE (PDH) ENZYME ACTIVITY IN BREAST CANCER CELLS WITH AND WITHOUT ESTROGEN RECEPTOR

Evaluation of IP3R3 Gene Silencing Effect on Pyruvate Dehydrogenase (PDH) Enzyme Activity in Breast Cancer Cells with and Without Estrogen Receptor

Background: Inositol 1,4,5-trisphosphate receptor (IP3R), a critical calcium ion (Ca2+) regulator, plays a vital role in breast cancer (BC) metabolism.Dysregulated IP3R in BC cells can drive abnormal growth or cell death.Estradiol increases IP3R type 3 (IP3R3) levels in BC, promoting cell proliferation and metabolic changes, including enhanced pyru

read more

Rhoptry Proteins ROP5 and ROP18 Are Major Murine Virulence Factors in Genetically Divergent South American Strains of Toxoplasma gondii.

Toxoplasma gondii has evolved a number of strategies to evade immune responses in its many hosts.Previous genetic mapping of crosses between clonal type 1, 2, and 3 strains of T.gondii, which are prevalent in Europe and North America, identified two rhoptry proteins, ROP5 and ROP18, that function together to block innate immune mechanisms activated

read more

School practices to promote social distancing in K-12 schools: review of influenza pandemic policies and practices

Abstract Background During an evolving influenza pandemic, community mitigation strategies, such as social distancing, can slow down virus transmission in schools and surrounding communities.To date, research on school practices to promote social distancing in primary and secondary schools has focused on prolonged school closure, with little attent

read more